Poster : Same-day selection of therapeutic antibodies by affinity and function using single B-cell screening

Same-day selection of therapeutic antibodies by affinity and function using single B-cell screening

Identifying the right antibody clone fast is the critical bottleneck in therapeutic discovery. Here we:

• Screened 40,000 B cells in a single run for affinity and multiple functional properties

• Selected neutralizing, cross-reactive, and internalized candidates

• Validated mechanism of action by pHSense and single-molecule nanoscopy

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