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Protein
Bioproduction

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Antibodies Made to Measure
Any Format, Any Scale

Our company is specialized in antibody production, offering custom formats at various scales while consistently meeting the required specifications.

Stage 1

High Throughout production at Microscale Hit discovery & screening

Stage 2

Small scale production
Lead selection

Stage 3

Medium & Large-scale production
Lead validation

Custom
reliable antibodies

We bring you exceptional results.

Fuel
Research

We offer precision antibody solutions.

Achieve tailor-made antibody success

We offer an integrated development process.

European Production

To support researchers, biotech, startups and pharma labs with tailored solutions.

From micrograms to grams

We deliver the quantity you need for your projects.

Custom Quotes or Integrated Project Solutions

Our comprehensive quality checks guarantee that every batch matches your exact needs.

Quality assurance

ISO 9001 certification guarantees the quality of our services.

This cloning step is carried out using sequences provided by the client or generated following single-cell selection on our Beacon platform. Each sequence undergoes codon optimization specific to the designated expression host (e.g., CHO, HEK293) to ensure optimal protein expression. A bank of versatile vectors was developed for antibodies, fragments or nanobodies. Thus, our engineered Fc library offers a variety of formats (different species, antibody type) and isotypes (e.g. bispecific antibodies with Fc silent or cysteine-engineered for conjugation). This process is fully automated on our high-throughput cloning platform, ensuring rapid and reproducible construct generation.
Immunoglobulins are cloned into expression vectors and are transiently transfected into mammalian expression systems 
(CHO or HEK293 cells). Both mammalian cell lines and expression vectors have been engineered to maximize productivity.
Classical of custom-made antibody formats can be produced based on client-specific requirements, such as monospecific, multispecific antibodies and antibody fragments 
(e.g., Fab, scFv, VHH).
An affinity chromatography step is performed and tailored to the specific antibody format. Depending on the target purity profile, additional downstream processing steps such as size-exclusion chromatography (SEC) or other polishing methods may be implemented to ensure removal of aggregates, fragments, or process-related impurities.
Antibody quality is verified through a series of quality control assays. Nucleic acid contamination are assessed by UV spectrophotometry. Purity and integrity are evaluated by SDS-PAGE under both reducing and non-reducing conditions to assess antibody fragmentation. Monomeric purity is determined via SEC-UPLC. Molecular mass of produced antibody is verified by LC-MS under reduced and deglycosylated conditions. Optional analyses can be performed in native and/or glycosylated states upon request. Endotoxin levels are quantified using the Limulus Amebocyte Lysate (LAL) assay. Our standard process yields low endotoxin levels for in vitro and in vivo use.

High-throughout antibody production

Express up to 96 antibodies in HEK293 systems, with custom formats, for functional screening such as EC50 determination, binding, and/or affinity assays.

HEK293 Expression System
From sequence to antibody delivery within a few weeks
Up to 800 µg
Included QCs on all hits* :
  • Concentration determination
  • Nucleic acid contamination evaluation
Included QCs on our internal control:
  • Productivity
  • Fragmentation and purity by SDS-PAGE
  • Aggregation and monomeric purity by SEC-UPLC
  • Endotoxin level
  • Antibody mass by LC-MS
*Additional QCs can be performed on demand

From small scale to large scale production

Accelerate your antibody development with flexible production, tailored to your needs. 
Express antibodies in HEK293 or CHO within weeks, in the desired format, from milligram 
to gram-scale yields. You’ll have the material you need for everything from in vitro assays 
to ADC generation and in vivo studies.

HEK or CHO Expression System
From sequence to antibody delivery within a few weeks
Mean productivity : 100 mg/L
Included QCs* :
  • Concentration determination
  • Nucleic acid contamination evaluation
  • Fragmentation and purity by SDS-PAGE
  • Agregation and monomeric purity by SEC-UPLC
  • Endotoxin level
  • Antibody mass verification by LC-MS
*Additionnal QCs can be performed on demand (glycosylation profil, native LC-MS, stability study

Our custom formats

From antigen design to final production

We offer end-to-end support with scientific rigor and flexibility. Whether for microscale R&D or preclinical studies, you can count on a reliable, responsive partner.

See the service

Trusted by scientists

As specialists in custom monoclonal antibody production, we support researchers, biotechs, startups and pharmas with tailored solutions.
Driven by quality. Built for innovation.

Every project is unique – We deliver the antibodies that match your needs

Let’s discuss your project
Contact an expert

Insights

Case study
Technical Note – Human CD3ε Knock-In Mouse Model: A Relevant Preclinical Tool for Bispecific T Cell Engagers

08/01/2026
Poster
A comprehensive discovery and engineering workflow for developing innovative anti-Nectin-4 antibody drug conjugates

08/01/2026
Event
At AACR2025

🧪 Heading to #AACR2025 and interested in advancing antibody discovery technologies? Join us at 𝗣𝗼𝘀𝘁𝗲𝗿 𝗟𝗕𝟬𝟬𝟯 on…

23/05/2025
Poster
Rapid Single-Cell Discovery of Tumor-Targeting Antibodies Using the Bruker Beacon® Platform for Therapeutic Development

12/05/2025
Event
AACR 2025 & our Poster

AACR 2025 – Heading to AACR Annual Meeting in Chicago ? Come meet our Chief Scientific Officer…

26/04/2025
Event
Festival of Biologics USA 2025

Festival of Biologics USA 2025 Meet Nathalie Joly our VP Business Development at Festival of Biologics USA…

16/04/2025
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